Final Projects Submitted for Credit in
Computational Molecular Biology
Biochemistry 218/ BioMedical Informatics 231
Selected Projects 2014
Anthony Chang - Artificial Nerual Networks in Protein Secondary Structure Predictions
Chenxi Chen - Review of Recent NGS Short Reads Alignment Tools
Eva Huang - A critical review of single-cell RNA sequencing-based genetic profiling for human embryo -s
Gergana Vandova - Critical assessment of phylogenetic algorithms
Bing Wu - Review of Computation for RNA-Seq Studies: Development and Improvement
Anne Ye - A Critical Review of Computational Protein Design Strategies: Progress, Limitations, and Improvements
Dana Yeo - Drug Repurposing
Samantha Zarati - A critical review of computational neurological models
Selected Projects 2013
Yang Bi - A critical review on chromatin architecture modeling with high throughput chromosome conformation capture techniques
Devon Chandler-Brown - Molecular Dynamics Simulations: Methods and Value in the Folding Problem
Paul Godden - Machine Learning for Genome-Wide Association Studies: A Critical Review
Yooli Light - Metatranscriptomic Pipeline Draft for Linking Functions to Microbes in Environmental Microbial Community
Lance Middleton - A critical review of MuTaME scoring for ceRNA predictions
Bojan Milic - From Whole-Cell Simulation to WholeCellKB: A Critical Review of Whole-Cell Computational Modeling
Charles Zheng - Frequentist tests of association for imputed genotypes
Simon Zheng - A Critical Review of Natural Language Processing Approaches to Discovering Drug-Drug Interactions from Medical Literatur
e
Selected Projects 2012
Yunqin Lee - Review of the Clustering and Feature Extraction Methods of Mass Cytometry
I. Lin - Discovering Transcription Factor Binding Motif Sequences
Dian Yang - A Critical Review of Gene Set Enrichment Analysis: Development and Improvement
Jake Wang - Critical Review of the Rosetta Algorithm
Alex Wilkinson- Computational Prediction of Protein-protein interaction
Samantha Woodward - A Critical Analysis of DNA Data Compression Method
s
Brian Yu - Comparison of Microarrayc and RNA-Seq Analysis Methods for Single Cell Transcriptiomics
Kristen Carnohan - Methods for Transmembrane Protein Topology and Alpha Helix Prediction
Clarence Cheng - Experimentally-guided computational RNA structure modeling
Caroline Townsend - A critical review of ChIP-seq enrichment analysis tools
Selected Projects 2011
Brand, Veronica - Degenerate Primer Design using Computational Tools
Constant, David - Template-Based Modeling of Protein Structure
Gopal, Nikhil - Comparison of Short Read De Novo Alignment Algorithms
Harris, Jason - Using MotifScan to Discover Transcription Factor Binding Sites in Non‐human Genomes
Lee, Ruby - A Critical Review of Strategies for Selecting Haplotype Tag SNPs
Ly, Nina -Evaluating Protein-Protein Docking Web Servers
Mayer-Blackwell, Koshian - Hunting the Monsters in the Database A critical review of computational tools for detecting chimeric 16S PCR amplification
Pauerstein, Philip - RNA-Seq: Current Methods and Potential Applications
Perez, Adam -Predicting Protein Complex Structures: A Review of the Docking Process
Ye, Simon - Considerations and Recent Advances in Molecular Dynamics
Zou, Amy - Multiple Sequence Alignments
Selected Projects 2010
Arul, Hari: A Review of Phylogenetic Trees and Their Function in Evolutionary Studies
Bhand, Maneesh: Handling Rearrangements in DNA Sequence Alignment
Blair, Stuart: A review of the Gene Ontology: past developments, present roles, and future possibilities
Boxer, Lisa: Hi-C: Genome-wide Chromosome Conformation Capture
Ghezelayagh, Talayeh: Analysis of the Computational Methods Available for MicroRNA Target Prediction
Guiney, Evan: Evaluation of currently available web-servers for 3D-structure based prediction of protein interface regions
Guo, Ming: Biological Pathways - A pathway to explore diseases mechanism
Hester, Jim: Comprehensive comparison of RNA-‐Seq alignment packages
Ito, William: A review of recent advances in ab initio protein folding by the Folding@home project
Kuenzel, Laney: Gene clustering methods for time series microarray data
Lee, Jong: Recent Advances in Statistical Methods for Genome-Wide Association Studies
Lim, Jaclyn: ChIP-Seq: The new way to ‘seq’ genome wide for transcription factor binding patterns
Sae-Seaw, Por: A review of graphical models for gene regulatory network inference using microarray data
Shiigi, Stacey: Mathematical models for designing synthetic ribosome binding sites to control protein expression in prokaryotes
Van de Mark, Daniel: The Numerous Caveats of Designing, Implementing, and Interpreting Genome-Wide Association Studies
Youngs, Noah: Progress in the Side-Chain Prediction Problem
Selected Projects 2009
Altman, Tomer: Large-Scale Alignment of Encyclopedic Metabolic Networks
Auburn, Mark: Recent Advances in the Determination of Three--Dimensional Chromosomal Conformation
Bettinger, Keith: The Phylo-HMM approach to problems in comparative genomics, with examples
.
Chung, Christina: Mapping Short Sequencing Reads: Challenges & Solutions
Davies, Kelli: Eukaryotic Gene Prediction
Dow, Graham: The limitation of genome wide association studies
Edris, Badreddin: A comparison of the Oligomap and TargetScan algorithms for miRNA target analysis
Gharegozlou, Roham: Protein Multiple Sequence Alignment: Benchmarks and Comparison
Naul, Brett: A Review of Support Vector Machines in Computational Biology
Singh, Simar: Sequence- and Structure-Based Functional Annotation
Tang, Grace: Critical Review of Functional Site Prediction
Wang, Jennifer: Protein Structure Prediction by Comparative Modeling: An analysis of methodology
Yang, Arthur: Analysis of Methodology in Cophylogenetic Studies
Selected Projects 2008
Li, Molong: Computational Methods of Discovering Gene Modules and Constructing Regulatory Networks
Sim, Adeline: Recent Developments in RNA Secondary Structure Prediction
Williams, Brandon: A Review on Common Applications Designed to Optimize the SEQUEST Search Algorithm With Respect to Limiting False Positive Identification
Min, Hye Young: A Review of Computational Methods for miRNA Target Prediction
Sutton, Shirley: Multiple Sequence Alignment: A Critical Comparison of Four Popular Programs
Tan, Meng How: Network Inference from Multiple Data Sources
Vinjamoori, Anant: Using Network Motif Analysis to Explore Transcriptional Regulatory Systems
Selected Projects 2007
Emerson, Tom: Conditional Random Fields for Classification of Protein Families: An Alternative to Hidden Markov Models
Goldstein, Ted: T-Tree, a new tool for taxonomy-based phylogenetic co-evolution analysis
Chen, Jennifer: Biological network analysis by division into modules, motifs, and themes based on physical and functional interactions between genes
Dennis, Steve: Simulating chromatin: Gene prediction at the structural level?
Shelef, Katie: A Critical Analysis of Degenerate Primer Design Programs
Keymer, Daniel: Efficiency and Accuracy of Phylogenetic Trees for Large Sequence Datasets
Li, Li: Pair Stochastic Context-Free Grammar Model in Comparative Sequence Analysis to Identify New Noncoding RNAs
Martinez-Alcantara, Antonio: SCFGs as Predictors of RNA's Secondary Structure
McElwain, Mark: A Critical Review of Gene Prediction Software
McPherson, Selwyn-Lloyd: Investigations Into a Genetic Algorithm for Protein Sequences
Ng, Chung W.: Inexact Pattern Matching Algorithms Via Automata
Peng, Chuang: Distance-Based Methods in Phylogenetic Tree Construction
Reitmaier, Rick: Review of Immunoinformatic Approaches to
In-silico
B-Cell Epitope Prediction
Verma, Seema: Bioinformatics Approaches to Biomarker Discovery
Selected Projects 2005
Carlson, Scott M.: Sequence Motifs are Necessary but not Sufficient for Predicting Post-translational Modifications
Hild II, Kenneth E. : Critical assessment of microarray analyses for gene identification
Kou, Charles : Analysis of Protein Structure Prediction by Homology Modeling
Patankar, Vishnu: Critical Analysis of the Computational Methods used to Discover Biomarkers to assist in the Early Detection of Disease
Ramamoorthy, Krithika : Critical Review of Methods available for Microarray Data Analysis
Sirota, Marina : Protein Multiple Alignment
Yu, Gang: Multivariate Projection Approaches for Microarray Analysis
Selected Projects 2004
Albert, Istevan: Predicting Protein-Protein Interactions with Collaborative Filtering Algorithms
Chan, Alexander: An Analysis of Pairwise Sequence Alignment Algorithm Complexities: Needleman-Wunsch, Smith-Waterman, FASTA, BLAST and Gapped BLAST
Choi, Jinkuk: A Critical Review of Computational Approaches on Finding Transcriptional Factor Binding Sites
Holbert, Daniel: Detecting motifs with EMOTIF-MAKER and MASIA: A critical comparison of two tools for finding protein motifs
Hwang, Andrew: Genotype Interpretation Algorithms: The Key to Resistance Testing for HIV-1
Lee, Jonathan: Analysis of Fundamental Exact and Inexact Pattern Matching Algorithms
Lo, Frederick: Three Recently Developed Algorithms for Aligning Distantly Related Proteins
Metzger, Ross: Multiple Alignment of Genomic Sequences
Mills, Brad: Towards Virtual Screening: Exploring the Potential (and Pitfalls) of Docking Software
Poon, Andy: Predicting Phosphorylation: A critique of the NetPhos program and potential alternatives
Sherwood, Rich: Trying on Phylogenetic Footprinting Methods
Sourirajan, Jayanthi: Protein Structure Prediction
Truong: A Critical Evaluation of Multiple Sequence Alignment
Watkins, Tara: Full-Atom Refinement Methods: The Key to High Resolution Protein Structure Prediction?
Selected Projects 2003
Ding, Yi : Singular Value Decomposition applied to the building of class predictor
Gunawardena, Shanti : Proteomics for the Discovery of Biomarkers and Diagnosis of Diseases
Huntzicker, Eric: Comparison of multiple sequence alignment algorithms
Knox, Kirstin : An Introduction To Motif Based Functional Classification of Large Protein Families
McGrath, Patrick: Uses of the Singular Value Decompositions in Biology
Moore, Chris Computational Methods of Identifying Novel sRNA Genes in
E. coli
Pootakham, Wirulda: Will You Find Me? A Critical Evaluation of Motif Finding Programs: BioProspector, MDscan, andConsensus
Potter, Brian: Improved Methods for Inferring Regulatory Networks from Temporal Expression Data
Silverman, Adam: A Critical Review of Computational Methods for RNA Secondary Structure Prediction
Smetana, Caroline Reiss: Data Analysis Methods for DNA Microarrays: A Critical Review of Applications to Breast Cancer Research
Tan, Elyn C.: A Critical Review of Statistical Methods for Differential Analysis of 2-sample Microarrays
Ching, Wendy: Applying Near-Optimal Alignments to Protein Structure Predictions
Choundhury, Rahul: Application of Evolutionary Algorithms for Multiple Sequence Alignment
Davies, Erin Lane: A Critical Review of Computational Methods Used to Manage Microarray Data Sets
Goepfer, Cecile: Bioinformatics and Learning: Will Machines Outsmart Humans?
Gordon, Michael: Methods of Phylogenetics Analysis: New Improvements on Old Methods
Jacob, Reza: Docking Algorithms of Virtual Ligand Screening
Middleton, Jack Larry: Combinatorial Relationships in Transcription Factors
Mikels, : Can HMMgene Net a Gene Too?: Analysis of Alternative Splicing/Gene Predicting Algorithms
Parker, David William: A Survey of Classification Methods for Protein Domain Motions and Flexibility
Srivastava, Sanjay: Analysis of Methods for Predicting Protein Fold and Remote Homologue Recognition
Zhang, Zhiyong: An Overview of Protein Structure Prediction: From Homology to Ab Initio
Selected Projects from 2002
Almstead, Laura: Secondary Structure Prediction of Proposed RNAi Targets: Can Current Energy Minimization Algorithms Be Used?
Anekonda, Thimmappa: Artificial Neural Networks and Hidden Markov Models for Predicting the Protein Structures: The Secondary Structure Prediction in Caspases
Awan, Ali:
In Silico
Transfer of Ligand Binding Function between Structurally Analogous Proteins
Bennett, Eric: Utilization of primary and secondary structure elements to predict a protein's propensity to form amyloids
Boerner, Joanna: Improving Structural Superpositions for Complex Protein Structures by Limiting Query to Single Domains
Brandt, Stephanie: R You Out There?: Computational Strategies for Identifying Resistance (R) Genes in Arabidopsis and Beyond
Butler, Thomas: Protein-Ligand Docking: A Critical Review of Molecular Dynamics, Robotics, and Rotamer Library Methods
Cevallos, Randal: A Poor Mans EVA: Examining the Accuracy of Secondary Structure Prediction
Chao, Elizabeth: Critical Analysis of secondary Structure Prediction Algorithms
Chen, William: A comparison of search algorithms in identifying all the proteins from the PROSITE protein database
Doukas, Tammy: Analysis of Ebola Glycoprotein Sequences from Strains of Varying Lethality
Edwards, John D.: Organism specific Amino Acid Substitution Matrices
Evans, Stacy: Horizontal Gene Transfer: Effect and Affect on Computational Methods
Frazier, Tamara: The Use of Computational Methods to Describe and Establish Utility of a DNA Sequence for Purposes of Patenting
Garg, Amit: A Go Model of Proteins and RNA
Gentile, Margaret: Computational Methods for the Design of PCR Primers for the Amplification of functional Markers from Environmental Samples
Hovijitra, Norman Tana: Computational Methods For Predicting Transmembrane Alpha Helices
Jayachandran, Guha: Constructing Nature's Building Blocks: An Analysis of Computational protein Design Today
Ki, Hwangmin: Microarray Data Analysis Methods Comparison : A Review
Koeva, Martina: Strengths and weaknesses of parsimony and distance methods, used in the PHYLIP 3.6 software package
Krishnan, Jagannath: Data Analysis of Villin Headpiece Subdomain Folding
MacDougall, Christina: Determination of Common Motifs in Proteins Found to Interact with TriC/CCT Subunits During Large-Scale Saccharomyces Cerevisiae Pulldown Experiments
Meehan, Joseph Foles III: Using Blocks in Pairwise Sequence Alignment
Patariu, David: A new Method of Analysis and Scoring Gene Expression Data
Radosevich, Jenny: Structural Considerations are Important when Performing Computer-Based Searches for Molecular Mimics
Ren, Pei-Hsien: eMOTIF Maker: Nodally Awesome: Comparing Results of eMOTIF Maker with Neighbor-Joining Trees
Sen, George: Finding genes by computational methods: An analysis of the methods and programs
Shah, Jessica Harendra: A Review of DNA Microarray Data Analysis
Shan, Lu: Analysis of The DQ Family of The Human Leukocyte Antigens
Stickney, Heather: Investigating the Mechanism of Follistatin Function with Bioinformatics
Tam, Stephen: Motif Finding in Upstream Regions of Chaperone Genes Downregulated in Response to Environmental Changes
Taylor, Matthew: A Comparative Analysis of Position Specific Scoring Matrixes for the Identification of Related Proteins
Tenenbaum, Jessica Dale: Integration of the Comprehensive Microbial Resource into the BioSPICE Data Warehouse
Vigdal, Thomas: Insertion Site Similarities in the TC1/Mariner Element Family
Wang, Stream: Prediction of Tight Junction Localization Signal(s) in the Mammalian Systems
Yang, Hang Wai Brian: A Parallel implementation of Smith-Waterman Sequence Comparison Algorithm
Yang, Yong: Comparative Analysis of Methods for Multiple Sequence Alignment
Yeo, Thomas: Using Information Theory to reduce Complexities of Neural Networks in Protein Secondary Structure Prediction
Selected Projects from 2001
Bair, Eric: An Improved Method for identifying Cell Cycle-regulatored Genes in Yeast
Burpo, John: A critical review of PCR primer design algorithms and crosshybridization case study.
Chain, Patrick: Examining the Current Problems of Whole Genome Comparison: A Review
Hua, Yuanyuan: A sequence based analysis of the structure of SNARE family N terminal domains
Lalush, David: Clique Scoring for Enhancing Protein Family Classification of Hidden Markov Models
Moraleda, Jorge: New Secondary Structure Prediction software package using automatically trained Bayesian Networks
Pai, Sukesh: A study of tree construction method in Phylogeny
Pulavarthi, Prasanth: Construction of a database of co-occurring eMtotifs based on conditional Probabilities
Reddy, Kirthi: Analysis of Caenorhabditis elegans protein T09E8.2
Segars, Paul: Quantitative Analysis of tRNA Sequences Using Information Theory
Schroeder, Jamie: Characterization of Hypervariability in Conotoxins
Varma, Chris: Molecular Mechanical Force Fields
Wenes, Geert: A Case study of transcriptional regulation in bacteriophage
l
- infected E. coli cells
Zhang, Nancy: Markov Models for Classification of Protein Helices